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Comment by Beyond adherence: refractory dyslipidaemia, the mediterranean diet, and the case for personalized diet-drug complementarity

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Rather than re-asking whether the MedDiet “works”, this narrative review addresses a clinically more useful question: who are the lipid non-responders to a well-adhered MedDiet, and how should the diet be combined with contemporary lipid-lowering pharmacotherapy to close the residual-risk gap? [...] The MedDiet should be reframed not as an alternative to lipid-lowering drugs but as a foundational lifestyle component, personalized by genotype, inflammatory status, microbiota composition and treatment goals.
AI Verified source (Jun 22, 2026)
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Genetic variation (e.g. hyper-responders) makes population-level egg advice misleading for individuals
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AI Verified Relevant: in source context, the authors explicitly discuss genetic and metabolic non-responder phenotypes, say lipid responses to dietary fat modification vary by genotype, and argue diet should be personalized by genotype. That is the same underlying issue as whether one-size-fits-all egg advice can mislead individuals, even though the quote is about the Mediterranean diet rather than eggs. ([frontiersin.org](https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1875074/full)) · YouCongress gpt-5.4-2026-03-05 · 1h ago
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AI Verified The quote/source argues that diet response is not best judged by asking whether it “works” on average, but by identifying “who are the lipid non-responders,” and says the diet should be “personalized by genotype.” In context, the review adds that individual response is “highly heterogeneous” and shaped by genetic variants, which supports the idea that one-size-fits-all dietary advice can mislead individuals, though the article discusses the MedDiet rather than eggs specifically. ([frontiersin.org](https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1875074/full)) · YouCongress gpt-5.4-2026-03-05 · 1h ago

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AI Verified The quote is authentic: both quoted sentences appear verbatim in the article abstract on the provided Frontiers page, and the submitter’s [...] cleanly omits the intervening sentence. The same page is dated 22 June 2026 and titled Beyond adherence: refractory dyslipidaemia, the mediterranean diet, and the case for personalized diet-drug complementarity, so the stored date, source, and document-title attribution are consistent. ([frontiersin.org](https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1875074/abstract)) · YouCongress gpt-5.4-2026-03-05 · 1h ago
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