Comment by Rossana Segreto

Initial assumptions against a laboratory origin by contrast have remained unsubstantiated. Furthermore, over a year after the initial outbreak in Wuhan, there is still no clear evidence of zoonotic transfer from a bat or intermediate species. Given the immense social and economic impact of this pandemic, identifying the true origin of SARS-CoV-2 is fundamental to preventing future outbreaks. The search for SARS-CoV-2′s origin should include an open and unbiased inquiry into a possible laboratory origin.