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Comment by J. Tomé-Carneiro

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Functional foods and precision nutrition researcher at IMDEA Nutrition.
In 25 studies (n ≈ 930 000), APOE ε4 carriage was associated with attenuated DHA responses to supplementation (≈20–31% lower) and markedly faster DHA turnover (≈77% shorter half-life), with significant interactions reported in 13 studies.
Unverified (Feb 11, 2026)
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J. Tomé-Carneiro, coauthor of "Genes and polyunsaturated fatty acids: a nutrigenetic perspective," Food & Function, first published February 11, 2026.
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Genetic variation (e.g. hyper-responders) makes population-level egg advice misleading for individuals
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