Comment by 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia

Although healthy eating patterns provide multiple cardiovascular benefits, including weight reduction, decreased inflammation, and improved control of blood pressure and glucose, the direct effect on LDL-C tends to be more modest. There may be individual variation in LDL-C lowering in response to dietary changes, particularly changes in saturated fat intake, which are influenced by bile acid production, reabsorption in the gut, and genetic polymorphisms.