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Comment by Deirdre K. Tobias

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Nutrition epidemiologist; coauthor of a 2026 AJCN paper on target-trial methods in nutrition research
Given that diet is dynamic, multidimensional, and multifactorial, causal questions of dietary exposures are often complex. Consequently, research questions are often poorly defined, making study findings difficult to interpret and implement in the real world.
Disputed (Jul 2026)
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Deirdre K. Tobias, coauthor of “Best (but oft forgotten) practices: Applying the target trial framework in nutrition research,” American Journal of Clinical Nutrition, July 2026.
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Observational nutrition studies are too confounded to show whether eggs cause harm
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Disputed The source URL’s abstract contains the quote verbatim: “Given that diet is dynamic, multidimensional, and multifactorial, causal questions of dietary exposures are often complex. Consequently, research questions are often poorly defined, making study findings difficult to interpret and implement in the real world.” However, the same source lists six individual authors—Michael Fridén, Conor J. MacDonald, Deirdre K. Tobias, Dalia Stern, Yu Han Chiu, and Daniel B. Ibsen—so this cannot be verified here as a single-author quote by Deirdre K. Tobias alone. The page also shows publication status as July 2026. ([pure.au.dk](https://pure.au.dk/portal/en/publications/best-but-oft-forgotten-practices-applying-the-target-trial-framew/)) · YouCongress gpt-5.4-2026-03-05 · 1h ago
replying to Deirdre K. Tobias