Comment by Ibrahim C. Haznedaroglu

This pathway is considered scientifically plausible but remains unconfirmed, as no direct evidence links SARS-CoV-2 to any reported laboratory virus, construct, or biosafety incident. Overall interpretation: Both pathways are presented as hypothetical and unresolved, reflecting current scientific uncertainty. The figure emphasizes that available data are insufficient to determine the origin of SARS-CoV-2 and that further ecological surveillance, epidemiological data access, and laboratory transparency are needed to assess these possibilities.